Neurosciences and psychotherapy: back to the basics

Authors

DOI:

https://doi.org/10.33898/rdp.v16i61.938

Keywords:

cognitive neurosciences, psychotherapy, stress, research, spatial working memory

Abstract

Cognitive neuroscience research has been recently advanced as central for a scientific foundation of psychotherapeutic treatment In fact, understanding how the maintenance, survival or neurological change is mediated psychological processes, is fundamental for advancing our knowledge about the mechanisms of psychotherapy treatment. This study is an attempt to bring psychotherapy closer to neurocognitive research in order to foster understanding on the neurobiological effects of therapeutic equivalent tasks in reverting the effects of chronic stress. More specifically, this study aims: (1) To compare spatial working memory and behavioural flexibility performances in groups of adult rats submitted to chronic unpredictable stress and age-matched controls; and (2) To test the modulatory effects of a cognitive treatment-equivalent task intended to counteract the effects of chronic unpredictable stress. The results confirm that stress impairs reference memory as well as spatial working memory and reversal learning tasks. More important, this study also demonstrates that the detrimental effects of stress on spatial working memory can be attenuated by a cognitive treatment equivalent task introduced in the late phase of the stress exposure, an effect that seems to be group (i.e., stressed animals) and task specific (i.e, spatial working memory).

Downloads

Download data is not yet available.

References

Altamura, A.C., Boin, F., & Maes, M. (1999) HPA axis and cytokines dysregulation in schizophrenia: potential implications for the antipsychotic treatment. European Neuropsychopharmacology10,1-4.

Barden, N. (2004) Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. Journal of Psychiatry Neurosciences, 29,185-193.

Cerqueira, J.J., Catania, C., Sotiropoulos, I., Schubert, M., Kalisch, R., Almeida, O.F.X., Auer, D.P., & Sousa, N. (2005) Corticosteroid status influences the volume of the rat cingulate cortex- a magnetic resonance imaging study. Journal of Psychiatry Research (in press)

Charney, D.S., & Manji, H.K. (2004) Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention. Sci STKE, 225: 5-10.

De Bruin, J.P., Sànchez-Santed, F., Heinsbroek, R.P., Donker, A., & Postmes, P. (1994) A behavioral analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioral flexibility, but not for impaired spatial navigation. Brain Research 652, 323–333.

Dias, R., & Aggleton, J.P. (2000) Effects of selective excitotoxic prefrontal lesions on acquisition of nonmatching- and matching-to-place in the T-maze in the rat: differential involvement of the prelimbic-infralimbic and anterior cingulate cortices in providing behavioral flexibility. European Journal of Neurosciences, 12, 4457-4466.

Fritts, M.E., Asbury, E.T., Horton, J.E., & Isaac, W.L. (1998) Medial prefrontal lesion deficits involving or sparing the prelimbic area in the rat. Physiol Behav 64, 373-380.

Goldman-Rakic, P.S. (1995) Architecture of the prefrontal cortex and the central executive. Ann N Y AcadSci 769, 71-83.

Greenlee, M.W., Berg, H, Stuhr, V, & Mergner, T (2000) Visual search and visual working memory in patients with chronic focal cortical lesions. Vision Research, 40, 3759-377 3.

Hamilton, K., & Dobson, K. (2001). Empirically supported treatments in psychology: Implications for international promotion and dissemination. International Journal of Clinical and Health Psychology, 1, 35-51.

Ilardi, S., & Feldman, D. (2001). The cognitive neuroscience paradigm: An unifying metatheoretical framework for the science and practice of clinical psychology. Journal of Clinical Psychology, 57, 1067-1088.

Kandel, E. (1998). A New Intellectual Framework for Psychiatry. American Journal of Psychiatry 155, 457-469.

Kesner, R.P. (2000) Subregional analysis of mnemonic functions of the prefrontal cortex in the rat. Psychobiology28, 219-228.

Kuhn, T. (1962). The structure of scientific revolutions. Chicago: The Chicago University Press.

Lacroix L, White I, & Feldon J (2002) Effect of excitotoxic lesions of rat medial prefrontal cortex on spatial memory. Behav Brain Res 133, 69-81.

Mcewen, B.S. (2000) Effects of adverse experiences for brain structure and function. Biological Psychiatry, 48,721-31.

Mizoguchi, K., Yuzurihara, M., Ishige, A., Sasaki, H., Chui, D.H., & Tabira, T. (2000) Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. Journal of Neurosciences 20,1568-1574.

Oades, R.D. (1981) Type of memory or attention? Impairments after lesions of the hippocampus and limbic ventral tegmentum. Brain Res Bull 7, 221-6.

Petrides, M. (2000) The role of the mid-dorsolateral prefrontal cortex in working memory. Exp Brain Res 133,44-54.

Prickaerts, J., Koopmans, G., Blokland, A., & SCHEEPENS, A. (2004). Learning and adult neurogenesis: Survival with or without proliferation? Neurobiology of Learning and Memory, 81, 1–11.

Rowe, J.B., & Passingham, R.E. (2001) Working memory for location and time: activity in prefrontal area46 relates to selection rather than maintenance in memory. Neuroimage 14, 77-86.

Salazar, R.F., White, W., Lacroix, L., Feldon, J., & White, I.M. (2004) NMDA lesions in the medial prefrontal cortex impair the ability to inhibit responses during reversal of a simple spatial discrimination. Behav Brain Res, 152, 413-424.

Schwartz, J., (1998). Neuroanatomical aspects of cognitive-behavioral therapy response in obsessive-compulsive disorder: An evolving perspective on brain and behavior. British Journal of Psychiatry, 173,38-44.

Sousa, N., & Almeida, O.F. (2002) Corticosteroids: sculptors of the hippocampal formation. Rev Neurosci 13,59-84.

Tyron, W. (2005). Possible mechanisms for why desensitization and exposure therapy work. Clinical Psychology Review, 25, 67-95.

Valenstein, E. (1988). Blaming the brain. NY: Free Press.

Published

2005-03-01

How to Cite

Gonçalves, Óscar F. ., Cerqueira, J. ., Guimarães, C. ., Belpalme, J., Amorim, L., Peixoto, M. ., & Sousa, N. (2005). Neurosciences and psychotherapy: back to the basics. Revista de Psicoterapia, 16(61), 65–75. https://doi.org/10.33898/rdp.v16i61.938