Reader Comments

Zz Snore

by Jerome Princy (2019-12-21)


Modafinil (Provigil) is Zz Snore Review another stimulant used to treat narcolepsy and sleep deprived individuals. It was approved by the FDA in 1998 and it has been used effectively by the US, the French, the British, and the Canadian militaries. Our Air Force refers to it as the "Go Pill," and it is used in aircraft where there are two pilots. Modafinil stimulates histamine production and it does not have the drastic side effects of the amphetamines. Nausea, dizziness, and vertigo have been reported in much lower frequency. The long term effects are still in question. Abuse potential is minimal, as is the cardiovascular stimulation found with the amphetamines. Neither amphetamine treatments, nor modafinil treatments attack the orexin deficiencies linked to narcolepsy. A study presented to the Associated Professional Sleep Societies in 2007 showed that histamine producing neurons and orexin producing neurons have direct roles in the control of wakefulness. The research concluded that both neurons have "synergistic and complimentary" roles. APD916, from Arena Pharmaceuticals, assists the histamine producing neurons and Orexin-A is a naturally occurring peptide in the brain. Both attack the deficiencies responsible for our sleepless and tired feelings and the symptoms of narcolepsy. A study conducted at Wake Forest University School of Medicine found that the effects of sleep deprivation were reversed when Orexin-A was administered to monkeys in either intravenous or intranasal formats. The intranasal spray produced superior results when compared to the intravenous injections. When the monkeys were not sleep deprived the Orexin-A did not have any effect on their performance levels. The potential for the intranasally administered Orexin-A is reported in Molecular Interventions. The spray's potential is far greater due to its ease of application and its quick results.

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